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Meadow Health is a physician-led telehealth platform focused on improving health outcomes for children with autism and related neurodevelopmental differences. Meadow Health combines evidence-based medicine, personalized care, and a family-centered approach—delivered securely via telehealth in all 50 states. Meadow Health is a service provided by Meadow Biosciences, Inc.

Meadow Health is designed for families of children with autism spectrum disorder (ASD) who are seeking: • Evidence-based medical care • Clinicians experienced in autism biology • Personalized treatment plans • Safe, reliable access to specialized therapies such as leucovorin (folinic acid)

Meadow Health is different because we: • Are physician-led, not coaching-only • Focus on the biological drivers of autism, not just behaviors • Use peer-reviewed science to guide care • Offer nationwide telehealth • Provide access to a dedicated, high-quality supply chain for leucovorin free of additives, dyes, lactose, or other ingredients which can negatively impact children with ASD • Design care around the whole child, not a one-size-fits-all model

Meadow Health clinicians may recommend: • Leucovorin (folinic acid) when medically appropriate • Targeted nutritional and metabolic support • Lifestyle and dietary strategies • Ongoing monitoring and care optimization All recommendations are individualized and based on medical history, clinical presentation, and current scientific evidence.

Leucovorin (also known as folinic acid) is a biologically active form of folate. Research has shown that, in a subset of children with autism, leucovorin may support: • Language development • Communication • Attention • Overall functional outcomes Meadow Health's clinical leadership includes investigators involved in the first double-blind, placebo-controlled trial of leucovorin in autism, as well as subsequent replication studies.

Leucovorin is an FDA-approved medication for specific indications. Its use in autism is considered off-label, which is common and accepted in pediatrics and medicine when supported by clinical evidence and physician judgment.

Leucovorin has a long history of clinical use and is generally well tolerated. As with any medical therapy, Meadow Health clinicians carefully: • Review medical history • Assess risks and benefits • Start with appropriate dosing • Monitor response and side effects Safety and responsible prescribing are core to Meadow Health's care model.

All care is delivered via secure telehealth: • Online intake and medical history • Clinician review • Telehealth consultation • Personalized care plan • Prescription fulfillment through vetted pharmacy partners • Ongoing follow-up and support Families can complete visits from home, on their schedule.

Meadow Health provides telemedicine services to patients in all 50 U.S. states and the District of Columbia, subject to provider licensure and applicable laws. For full provider information and to be in compliance with Massachusetts, Rhode Island, and Vermont telemedicine state laws, patients are instructed to access full provider lists via mdintegrations.com Jurisdictions served include all 50 U.S. states and the District of Columbia, through a network of U.S.-licensed clinicians who are appropriately licensed in the state where the patient is located at the time of the encounter. Exhaustive list of jurisdictions served: Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, Wyoming, District of Columbia

At this time, Meadow Health operates as a self-pay service. This allows us to: • Spend more time with families • Avoid insurance-driven limitations • Maintain rapid access and continuity of care Pricing is transparent and shared upfront, with no hidden fees.

Yes. Meadow Health is designed to complement, not replace, existing services such as: • ABA • Speech therapy • Occupational therapy • Educational supports Many families use Meadow Health as the medical foundation that supports progress across therapies.

No. Meadow Health is available to anyone on the ASD spectrum, Neuroimmune spectrum (PANS/PANDAS), refractory depression (folate metabolic dysfunction and low spinal fluid folate levels have been found in adults that have not responded to conventional psychiatric treatment), as well as emerging research related to neurodegeneration and aging in which folate levels decrease as we age and are associated with increased risks for Parkinson's Disease, certain dementias, such as Alzheimer's, and may help prevent age related cognitive decline. Evidence is also starting to link long-COVID, Chronic Fatigue Syndrome/myalgic encephalomyelitis (CFS/ME), and mitochondrial dysfunction to low spinal fluid (CSF) folate levels in which an empirical trial of leucovorin (folinic acid) may be clinically advised. Pregnant women that are in need of high quality folate interventions for pre-conception and pregnancy may also benefit from high dose leucovorin.

Meadow Health may be a good fit if you: • Want medically guided, evidence-based care • Are interested in understanding the biology behind your child's symptoms • Value clinician access and continuity • Prefer a thoughtful, personalized approach Our intake process helps determine whether Meadow Health is appropriate for your child before moving forward.

You can get started by: • Visiting our website • Creating an account • Completing the intake questionnaire • Scheduling your first telehealth visit Our team is here to guide you every step of the way.

No. Meadow Health was built by clinicians and researchers who have spent over 15 years translating autism research into clinical care. Our goal is not to sell false promises, but to responsibly deliver evidence-based care that has historically been difficult for families to access. We are transparent about: • What is known • What is still being studied • What Meadow Health can and cannot do Hope matters—but it must be backed by science.