At Meadow Health, everything we do is grounded in rigorous scientific research and real-world clinical experience.
Our care model is built on decades of peer-reviewed studies investigating the biological contributors to autism and related neurodevelopmental conditions—and how targeted, evidence-based interventions can help support children's development, health, and quality of life.
Autism is not a single condition with a single cause. Research shows it involves multiple biological systems, including:
Folate Metabolism
Learn More →Gut-brain Communication
Learn More →Immune Signaling & Inflammation
Learn More →Brain & Mitochondrial Energy Production
Learn More →Understanding which pathways matter for which child is the foundation of personalized, responsible care.
Folinic Acid (Leucovorin) in Autism
One of the most influential studies in this field is the 2016 randomized, double-blind, placebo-controlled clinical trial published in Molecular Psychiatry:
Why This Study Is Important?
It was a gold-standard clinical trial (randomized, double-blind, placebo-controlled)
It focused on verbal communication, a core challenge for many children with autism
It identified a biological subgroup—children with folate receptor alpha autoantibodies (FRAA)—who showed the greatest benefit
It demonstrated that folinic acid (leucovorin) could significantly improve outcomes when used appropriately and monitored clinically
Frye, Slattery et al., 2016
“Folinic acid improves verbal communication in children with autism and language impairment.”
One of Meadow Health's founders was the second author and a co-investigator on this landmark trial.
This means our leadership team didn't just read about this research—we helped generate it, analyze it, and translate it into clinical practice.
That experience informs:
How we evaluate children
How we prescribe and dose leucovorin
How we monitor safety and response
How we educate families and clinicians
Leucovorin is not a one-size-fits-all solution
This growing body of evidence reinforces that leucovorin is not a one-size-fits-all solution, but a biologically targeted therapy that can be meaningful for the right child when used responsibly.
Replicated in multiple independent studies
Supported by growing research on folate transport, autoantibodies, and brain metabolism
Integrated into broader systems-biology models of autism
From research to care
Meadow Health was built to close that gap—by translating high-quality research into safe, personalized, accessible care, delivered by trained clinicians through a national telehealth model.
Many families struggle to access care that is:
Evidence-based
Biologically informed
Clinically supervised
Free from unnecessary fillers, dyes, and shortcuts
Advancing Autism Care Through Research
Closing the research-to-care gap by providing safe, personalized, accessible care. Our trained clinicians deliver care through our national telehealth program.
We remain committed to:
Scientific integrity
Transparency with families
Ongoing research and learning
Putting children's health and wellbeing first
Want to Learn More?
For families interested in the science behind Meadow Health—or how research informs your child's care—our team is always happy to help. For more information, visit meadowbiosciences.com
Join us and be one of the first 100 Meadow families
Lock in $200/month pricing, work with experienced clinicians who understand autism, and explore leucovorin in a structured, science-aware way. No pressure, no hype—just careful support for your child's folate pathway and your family's journey.
